Platelet adhesion

Primary platelet adhesion receptors.

Thrombotic diseases such as heart attack and stroke remain a major health concern in the Western world despite existing anti-thrombotic drugs. Current studies are revealing structure-function relationships of primary platelet adhesion receptors mediating adhesion, activation and aggregation, and the molecular mechanisms underlying platelet thrombus formation. Platelet adhesion is relevant not o...

Integrin-mediated platelet adhesion.

Adhesion of platelets to the damaged subendothelium is a prerequisite reaction for the initiation of hemostasis in vivo. Platelet membranes contain high concentrations of integrins and other glycoproteins (GPs) that are involved in the platelet adhesion to the extracellular matrix. In the present review, we focus on two platelet integrins, integrin alphaIIb beta3 (GPIIb/IIIa) and integrin alpha...

Inhibitors of platelet adhesion.

Platelet aggregation, in fundamental terms, is considered a biological end point that contributes to the occurrence of clinical events among patients with advanced atherosclerotic coronary artery disease. Acute coronary syndrome, including non–ST elevation myocardial infarction (NSTEMI) and ST elevation myocardial infarction (STEMI), accounts for upward of 733 000 hospital admissions yearly in ...

Platelet Endothelial Cell Adhesion Molecule

Platelet adhesion to surface caPtured

Type 2A Von Willebrand disease (VWD) is clinically identified by a loss of high and intermediate Von Willebrand factor (VWF) multimers resulting in a loss of platelet-dependent function. The majority of mutations that cause type 2A disease occur in the A2 domain and are grouped by their effects on cellular retention of VWF or the susceptibility of VWF to proteolysis by ADAMTS13. However, a few ...